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[10] Other uncommon adverse effects reported with very high doses include dermatological lesions (photosensitivity and skin rash), gastrointestinal upset, and in some cases dependency syndromes (e.g

Chronic high-dose vitamin B intake (generally in gram quantities daily over many months) has been linked to severe sensory neuropathy characterized by numbness, impaired proprioception, and paresthesia in a stocking-glove distribution