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Additionally, disclose if you have a history of heart issues, kidney disease, liver disease or a specific blood disorder called methemoglobinemia

Some conditions like autoimmune thyroid disease, surgical gland removal, or advanced ovarian failure may limit how far levels normalize, but symptom relief is still often significant

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[67] found that both moderate and severe ME/CFS have reduced mitochondrial function, and severe ME/CFS also have glycolytic impairments with higher rates of respiratory acidification