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Iron Chelator Research: Past, Present, and Future

i) The key to the treatment of cirrhosis is etiological treatment

The interaction between iron regulatory elements ( IREs ) and iron regulatory proteins ( IRPs ) ensures that iron is appropriately utilized and stored, further connecting heme metabolism with iron recycling [21, 22]

Iron is indispensable for cellular metabolism and energy production in the brain as a core component of cytochromes [17] and ironsulfur clusters [18], which are fundamental to the electron transport chain in mitochondria [19]