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Anti-inflammatory role of 15-lipoxygenase contributes to the maintenance of skin integrity in mice

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Meng et al (118) revealed that the PGE2-stimulated gene expression of PG EP3 receptor subtype led to intracellular cAMP reduction, accompanied by a downregulated phosphorylation level of Akt and forkhead box 'Other' (Foxo) in HIT-T15 cells (118)

Key Points Non-alcoholic fatty liver disease (NAFLD), the most common chronic liver disease, encompasses a histological spectrum ranging from simple steatosis to non-alcoholic steatohepatitis (NASH), the latter of which has varying degrees of fibrosis

"Si bien estos resultados no significan un cambio en las recomendaciones actuales, los cientficos nos han dado un buen recordatorio de que debemos pensar en fuentes alternativas de protenas si comemos mucha carne roja o procesada", agreg

The mechanism involves protecting neuronal mitochondria from oxidative stress while supporting neurotransmitter synthesis pathways