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Their structural simplicity, compared to antibodies, often results in weaker targeting specificity, which may lead to off-target accumulation and increased toxicity [229]

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Headache is reported by some users, typically mild and decreasing with continued use

Administration of BmK IT2 markedly prolonged the latency to SE onset, attenuated SE severity, and suppressed hippocampal c-Fos expression during epileptogenesis, suggesting its role in modulating neuronal hyperexcitability (Zhao et al., 2008)

Exposure of fluoride with streptozotocin-induced diabetes aggravates testicular damage and spermatozoa parameters in mice

For drugs with a narrow therapeutic margin, such as digoxin, the aminoglycosides, and theophylline, the individualization of the dosage regimen is very important