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[DOI] [PubMed] [Google Scholar] 11.Qiu L, List EO, Kopchick JJ

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Mayo and colleagues identified the GHRH receptor as a pituitary-specific G-protein-coupled receptor of the secretin/VIP (family B) class, [4] a seven-transmembrane receptor that mediates GHRH-induced cAMP accumulation and growth-hormone release, [5] and which, beyond acute GH release, drives somatotroph proliferation

Stimulatory Factors: Inhibitory Factors: Pulsatile Secretion: Why Timing Matters GH is not released continuouslyit follows a pulsatile pattern with distinct secretory bursts, particularly during deep sleep, exercise, fasting states, and stress responses