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Administration of proteolytic enzymes bromelain and trypsin diminish the number of CD4+ cells and the interferon-gamma response in Peyer's patches and spleen in endotoxemic balb/c mice

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Abbreviations MASH : Metabolic dysfunction-associated steatohepatitis MASLD : Metabolic dysfunction-associated fatty liver disease HF/HFD : High-fructose/high-fat diet DMSO : Dimethylsulfoxide Mito : Mitoglitazone Pro : Proanthocyanidin ALT : Alanine aminotransferase AST : Aspartate aminotransferase sTfR1 : Soluble transferrin receptor-1 ACSL4 : Acyl-CoA synthetase long-chain family member 4 GPX4 : Glutathione peroxidase-4 GPX : Glutathione peroxidase GSH : Glutathione ROS : Reactive oxygen species LPO : Lipid peroxidation HOMA-IR : Homeostatic model assessment for insulin resistance AMPK : Adenosine monophosphate-activated protein kinase References Ameka MK, Hasty AH (2022) Paying the iron price: Liver iron homeostasis and metabolic disease