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Immunostimulation with chemotherapy in the era of immune checkpoint inhibitors

Quraishi MN, Widlak M, Bhala N, Moore D, Price M, Sharma N, et al

10.1073/pnas.1604570113 114

fTHF, 10-formyltetrahydrofolate

A complex consisting of Cullin 3 (Cul3), KEAP1, and ring-box 1 (RBX1) binds to E2 ubiquitin-conjugating enzyme, and Nrf2 and Nedd8 (N8) induce a conformational change that inhibits Nrf2 ubiquitination (Reuter et al., 2010)