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Circadian gene Bmal1 regulates diurnal oscillations of Ly6Chi inflammatory monocytes

An increasing number of studies indicate that zinc plays a significant role in bone tissues normal development and maintaining homeostasis

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In the extracellular space, HMGB1 mediates inflammation or tissue repair, according to its redox state

The ideal therapeutic compound for TBI and CNS diseases should have PK-PD criteria such as smaller molecular weight, moderately lipophilic, low plasma protein binding affinity, higher distribution volume, and serve as weak ligand of P-glycoprotein or another efflux pump located at the BCB [44]

The reality is more complicated