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ROS can oxidatively modify regulatory subunits of the IB kinase (IKK) complex, promoting IB phosphorylation and subsequent degradation via the ubiquitin-proteasome pathway, thereby releasing active NF-B dimers (e.g., p50-p65) for nuclear translocation (S-Pessoa et al., 2023

3.1 IL-6/IL-6R with different inhibitors One meta-analysis of IL-6 concentration levels found that patients with complicated COVID-19 had 2.9-fold higher levels than those with uncomplicated disease (Ulhaq and Soraya, 2020), indicating that the IL-6 level was a perfect predictor of poor prognosis in COVID-19 (Table 2

The OxyR-regulated phnW gene encoding 2-aminoethylphosphonate: pyruvate aminotransferase helps protect Pseudomonas aeruginosa from tert -butyl hydroperoxide

When designing light-activatable prodrugs, by covalently connecting chemotherapy drugs with photosensitizers through a ROS-sensitive TK bond, the targeting specificity of the chemotherapy drugs can be enhanced, side effects can be reduced, and the distribution of the drugs in the body can be optimized [59]

The incidence of varices in cirrhotic patients without varices at baseline is 59% at 1 year and 1417% at 2 years [6,7]

"Mechanical injury potentiates proteoglycan catabolism induced by interleukin6 with soluble interleukin6 receptor and tumor necrosis factor in immature bovine and adult human articular cartilage." Arthritis & Rheumatism: Official Journal of the American College of Rheumatology 60.10 (2009): 2985-2996