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Only a small amount in the plasma is free and active, most is bound to globulin or albumin

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A phase 2 randomised controlled trial published in the New England Journal of Medicine (2023) reported substantial weight loss and improvements in glycaemic parameters, though the trial was conducted in a closely monitored clinical setting with defined eligibility criteria

Quick Takeaways Human sleep trials used 25 nmol/kg IV for 7 consecutive nights The commonly used 100250 mcg subcutaneous protocol lacks direct clinical validation DSIP demonstrates an unusually wide safety margin in animal and human research Most evidence comes from small 1980s pilot studies, not modern RCTs What DSIP Actually Is (And Why Its Misunderstood) DSIP is a nine-amino-acid neuropeptide first isolated in 1977 from the cerebral venous blood of sleeping rabbits