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Statements Author contributions AT, RP, JB, BI, and YG conceived the idea and wrote the manuscript

Originally containing the important cytosolic CXC motif, CD4 then underwent rapid evolution at two distinct protein-protein interaction sites in D1 and D2, both bearing important Cys residues

Unmyelinated axons on the other hand have a small diameter generally less than 0.2 m in the central nervous system and less than 1 m in the peripheral nervous system

Speciation of reactive sulfur species and their reactions with alkylating agents: do we have any clue about what is present inside the cell

Notably, Kupffer cells also play a critical role in liver regeneration

Depending on the nature of this final cleavage, the procedure can be modified to give a C-terminal acyl thiocyanate peptide product which automatically rearranges to a thiohydantoin incorporating the penultimate C-terminal unit