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Blood samples were collected at Pre, 0.0833, 0.25, 0.5, 1, 2, 4, 8, 24, 48 and 72 h after IV administration (10 mg/kg (mpk)) and Pre, 0.25, 0.5, 1, 2, 4, 8 and 24 h after PO administration (100 mpk)

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Moreover, aging appears to be associated with a decline in neutrophil efficiency, as evidenced by impaired phagocytosis and oxidative burst, reduced cytokine production, and altered chemotaxis, 516 which increases the susceptibility of older people to infections and inflammatory diseases

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493,494 Furthermore, the introduced nanosized carriers could give protection to the loaded therapeutics that significantly extended the function duration with reduced degradation speed in vivo