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Mucoadhesive nanostructured lipid carriers as a cannabidiol nasal delivery system for the treatment of neuropathic pain

N-acetylcysteine amide protects against methamphetamine-induced tissue damage in CD-1 mice

DOI: 10.1073/pnas.0438010100 Nicolaou, K.C., Evans, R.M., Roecker, A.J., Hughes, R., Downes, M., Pfefferkorn, J.A

Goal: Support cognitive function, attention, and neuroprotective pathways studied in clinical literature [2] [5]

Independent of the trigger of neurodegeneration leading to AD, PD, HD or ALS, common pathological themes emerge: excitotoxicity, mitochondrial dysfunction, oxidative stress, glial and vascular dysfunction, often interacting in complex, cascading patterns

As a result, E3 ubiquitin ligases, which select substrates for ubiquitylation, serve as regulatory gatekeepers of myriad biological processes, including biologically critical functions such as protein homeostasis and quality control, cell cycle, and the DNA damage response (Kulathu & Komander, 2012