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TMA syndromes require rapid intervention with plasmapheresis, immunosuppressive agents (corticosteroids), or complement-inhibiting therapies (e.g., eculizumab) due to their natural pathophysiology of endothelial damage and complement dysregulation

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Sleep architecture is assessed through patient history or, where available, actigraphy or polysomnography data specifically sleep latency, REM and slow-wave sleep proportions, and sleep fragmentation index