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Following the addition of GSH in the culture medium, the decrease in cell index is fast and marked reaching almost basal values, occurring within 2-3 hours (Figure 1A)

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1-carboxyphenyalanine is reported to be associated with poor response to metformin (Naja et al., 2023) and with lower microbiome diversity (Wilmanski et al., 2019), and previously shown to be most discriminating metabolite of insulin resistance (ahin et al., 2022)

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Mechanistic studies indicate that curcumin reduces the levels of pro-inflammatory cytokines (IL-1, IL-6, IL-18, and TNF-) in intestinal tissues, thereby alleviating intestinal inflammation