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however, because only about 620% of B 12 in the blood is active holoTC, even people with total B 12 levels in the normal range may have a functional B 12 deficiency

Explain that a transfusion of packed RBCs may be needed

They sell preserved and unpreserved hydroxyB-12

Data compiled by SHOOK Research LLC based on the time period from 3/31/23 - 3/31/24

This work paves the way to clinical trials repurposing these compounds to promote brain repair in the context of both early- and late-life-onset myelin pathologies such as PBI and MS

Groups at higher risk of deficiency include older adults (due to reduced stomach acid production), people following vegan or strict vegetarian diets (as B12 is naturally found almost exclusively in animal products), individuals with pernicious anaemia or other malabsorption conditions, those taking certain medications such as metformin or proton pump inhibitors long-term, and people with significant nitrous oxide exposure (including recreational use), which can inactivate B12 in the body