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Hydroxyurea (HU), a sickle cell disease (SCD) drug approved by FDA, shows protective effect in nephropathy

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However, it triggers apoptosis in erythroid precursors in the case of cytokine deprivation to prevent expansion of erythroblasts and to control the number of erythrocytes under stress conditions [99]

According to Sozaski et al., dimethylarginine species, i.e., asymmetric dimethylarginine and symmetric dimethylarginine (ADMA and SDMA) are known as cardiovascular disorder markers