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Here, we review accumulating evidence suggesting that histamine indeed has roles in inflammation and immune function modulation in such diseases

Appropriate in vitro transformation studies can be selected according to the administration route and possible transformation route to investigate the stability of the prodrug: In vitro transformation experiments under different pH conditions, such as artificial intestinal fluid or gastric fluid stability experiments, to determine the transformation rate and degree of prodrugs under various pH conditions

doi: 10.1007/s11883-024-01251-1

Anti-inflammatory action of ginger: A critical review in anemia of inflammation and its future aspects

Prodrugs were essentially undetectable in plasma within 0.25 h after 1 h of intravenous infusion, and the exposure to the drug was less than 1% of that of the active drug

doi: 10.1523/jneurosci.5692-10.2011 72