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However, drug use and unhealthy diet lead to microbial dysbiosis, triggering metabolic disorders and adversely affecting kidney health ( Figure 2 ) [24, 36]

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Since selenium supplementation in the forms of sodium selenite and SeM was well documented to induce the expressions of seleno-GPxs through their metabolic assimilation into bioavailable selenium (hydrogen selenide), the initial studies focused on exploring selenium supplementation as a strategy to achieve protection against radiation-induced toxicity [38, 66]