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Mitochondria also regulate crucial pathways including calcium homeostasis and reactive oxygen species (ROS) production which are critical for neuronal plasticity [5]

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HIF cooperates with distinct TF families in the kidney within defined hierarchical promoter structures As a combination of multiple interacting TFs is needed for the expression of a specific gene transcript, we hypothesized that there were TF families that cooperated with HIF to dictate the synchronized expression of genes linked to hypoxic stress

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However , some local side effects are possible