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Hydroxylation of naringenin by flavanone 3-hydroxylase (F3H) and flavonoid 3-hydroxylase (F3H) produces dihydroflavonols, from which dihydroflavonol reductase (DFR) produces leucoanthocyanidins (Figure 4)

120 In myeloid cell-specific SIRT1 knockout mice, lipid toxicity or LPS stimulation induced more severe hepatic inflammation, elevated pro-inflammatory cytokine levels, and enhanced M1 macrophage polarization, highlighting the critical role of SIRT1 in preserving immune balance

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Het wordt vaak de meester-antioxidant genoemd vanwege zijn centrale rol bij het neutraliseren van vrije radicalen, het recyclen van andere antioxidanten zoals vitamine C en E, en het ondersteunen van de leverontgifting

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