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Importantly, these changes in mitochondrial mass are not related to engagement of apoptosis: inhibition of caspase activity using zVAD-fmk did not prevent increases in mitochondrial abundance per cell (Extended Data Fig

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Moreover, treatment with a reducing agent that prevents disulfide stress, such as tris(2-carboxyethyl)phosphine (TCEP), specifically suppressed glucose deprivation-induced shGDH1 cell death (Extended Data Fig

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2025 Jun;15(6):e70385

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Cross talk between engulfment receptors stabilin-2 and integrin v5 orchestrates engulfment of phosphatidylserine-exposed erythrocytes

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7G) in the knockout group further supported apoptosis induction

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[PMC free article: PMC4139706] [PubMed: 25053660] 437

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