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The order below moves from the best-documented effects to the most situation-specific: local skin reactions first, then copper-specific contact allergy, then the microneedling-related risks that attach to a common delivery method, and finally an honest accounting of the thin safety data and the theoretical copper-accumulation question

No peer-reviewed study has directly demonstrated that topical GHK-Cu reduces DHT or inhibits 5-alpha reductase in human tissue

We recommend performing a patch test prior to full use to ensure compatibility with your skin type Lather soap and apply to treatment areas

In practice this is one drop per eye, per day (when using as a drop) or one drop per eye and one drop on each mask pad, per day (when using with AMEYEZ)

[DOI] [PubMed] [Google Scholar] 156.Wang S, Shang S, Lv J, Hou D