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BC, Lysyl oxidase converts lysine amino groups to aldehydes, which react with other lysines to form simple linear cross-links or six-membered rings linking two polypeptides

Parkinsons disease is a neurodegenerative condition affecting one to two percent of the population, for which there is no known cure

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To next validate efficacy in an immune-competent autochthonous mouse model, we made use of an established genetically engineered mouse model (GEMM) recapitulating all relevant features of human SCLC 53

Neuronal clustering Neurons were clustered (resolution = 1), yielding 55 major clusters split by neurotransmitter identity ( Slc32a1 , Slc17a6 , Chat , Slc6a4 )

10.1007/s00401-015-1513-1 Acta Neuropathol