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First, the model employed -naphthylisothiocyanate-induced cholestasis, which is an acute injury model

Shinto L, Quinn J, Montine T, Dodge HH, Woodward W, Baldauf-Wagner S, Waichunas D, Bumgarner L, Bourdette D, Silbert L, Kaye J (2014) A randomized placebo-controlled pilot trial of omega-3 fatty acids and alpha lipoic acid in Alzheimers disease

7c), but the mice received XMU-MP-1 prior to KA injection (KA + XMU-MP-1 mice) required additional injection of KA to reach to the same seizure stage compared to that in DMSO-pretreated epileptic mice (KA + DMSO mice)

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6668 5-hydroxytryptophan is generated from tryptophan through the catalysis of tryptophan hydroxylase and then converted into serotonin by the catalysis of 5-hydroxytryptophan decarboxylase

KO clones lacking each cell death executor were created using CRISPRCas9 technology