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We showed that RSPO2-deficient mice have reduced active -catenin signalling and a decreased mineral deposition rate and osteoblast number, similar to the phenotype observed with the knockout of LRP5/6

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In the context of AD and other neurodegenerative disorders, silk nanoparticles enable versatile therapeutic delivery, including drugs and other active agents targeting specific cell types (Mathur and Gupta, 2010) and have demonstrated the ability to bypass the BBB and reach deep brain regions (Yonesi et al., 2021)

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