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Annu Rev Pharmacol Toxicol 53:401426

7.4 Gut microbiota dysbiosis and metabolic-endocrine crosstalk The gradual buildup of abnormal protein aggregates in the central nervous system (CNS) is a key characteristic of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS) (129)

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