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15 The gene for glutathione peroxidase-4 is expressed in most tissues, including the brain (Gene Expression Atlas, available at Although the GPX4 gene is highly polymorphic, a limited number of studies 16, 17, 18, 19 have been done to investigate genetic variations within the GPX4 gene that could potentially alter the function of the enzyme

(Basel) 10 (4), 674

Science 285(5431): 1268-1271

Ebeling M Letter: ANNALS OF PHYSICAL AND REHABILITATION MEDICINE

A fascinating study revealed that combining autophagy suppression with inhibition of tyrosine kinase activity can have a synergistic effect in treating glioma [184]