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Moreover, the same group showed that HIF-1 stabilization by dimethyloxalylglycine (DMOG) modulates the macrophage phenotype by restoring M1 metabolism (244)

The effects of gene perturbations were measured in competitive proliferation assays of Cas9 - and sgRNA/IRFP670-expressing MOLM-13 AML cells over time (Supplementary Fig

These adaptor proteins form a signaling complex that activates TGF-activated kinase 1 (TAK1), which is an upstream kinase in the NF-B signaling cascade [134]