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Surprisingly, multiple ALS-causative mutations in FUS/TLS increase FUS/TLS interaction with SMN, thereby affecting the normal function of SMN by both reducing Gem bodies and changing steady-state levels of some snRNAs in transgenic mouse tissues and patient fibroblasts expressing mutant FUS/TLS

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10.1128/spectrum.04417-22 114 ShenN.-Y.BiJ.-B.ZhangJ.-Y.ZhangS.-M.GuJ.-X.QuK.et al (2017)

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