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& Ghali, W

Animal studies have revealed cognitive deficits and anxiety-like behaviors in mice following exposure to the spike protein, possibly due to non-cell autonomous death of neurons in the hippocampus [23]

For instance, increased levels of IL-6 can upregulate MCP-1 expression in endothelial cells and macrophages, establishing a positive feedback loop that amplifies the inflammatory response (137)

doi: 10.1038/s41598-024-76825-9 83 ItoJShirasunaKKuwayamaTIwataH

PMID: 40953614 Int J Biol MacromolPI4KB is an essential host factor for duck hepatitis a virus 1 replication and translation

This also correlated with a sepiapterin-induced reduction in nitrotyrosine (NT) levels which was more pronounced in WT mice than the Hph-1 littermates