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Moreover, signaling pathways commonly associated with stemness, notably the Notch, Hedgehog, and PI3K/AKT/mTOR pathways, intersect with metabolic regulators, forming feedback loops that tightly control energy production, biosynthesis, and cell fate decisions

Morrison et al

Evidence also suggests that natural expression of the peptide increases in brain regions affected by injury, hinting at a possible role in adaptive responses

The third potential key role in the development of chronic inflammation that leads to airway remodeling in asthma and obesity is the role of inflammasome

Preclinical studies have demonstrated that Epithalon activates telomerase in somatic cells through activation of telomerase reverse transcriptase, which promotes telomere elongation, and delays cellular senescence

Available online at: (Accessed September 26, 2025)