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In my three decades of direct observation and collaboration with leading clinicians, Ive seen consistent therapeutic responses with once-daily and twice-daily dosing protocols

Although Serum B12 showed a downward trend with the increase of MMA level, B12 in most patients is still higher than the cutoff value of B12 deficiency ( 250 nmol/L, about 47% had serum B12 more than 400 pg/mL

J Biol Chem (2004) 279(33):3434352

Because sensitization of afferent fibers to mechanical stimuli is correlated with behavioral results, sensitization may contribute to the reduced withdrawal threshold after incision

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Its thought that vitamin B6 (pyridoxine) could be the B vitamin most associated with mood disorders, including anxiety, stress, and depression