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Melatonin reprograms the effector state of activated ILC2s To further dissect the effects we had observed, we isolated aILC2s from IL-33 challenged BALB/c mice ( Supplementary Figures 2 ) and performed bulk RNA sequencing, comparing the transcriptome of vehicle and melatonin treated cells ( Figure 5A )

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As a proof of concept, local Slc38a3 silencing using vivo morpholino technique resulted in astrocytic swelling and increased volume of the brain region subjected to silencing (Hamdani et al., 2021)

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This is not surprising considering that a loss of OHC and IHC produces the loss of trophic targets of primary afferents coming from the spiral ganglion

Grange et al., 2021)