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pathologically affected tissues in murine models of SOD1 linked familial ALS are enriched in soluble misfolded SOD1 prior to disease onset, whereas SOD1 aggregates increase markedly after symptom onset

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10.1242/jcs.259340 201 Van LithM.TiwariS.PedianiJ.MilliganG.BulleidN

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If taking higher doses, it is highly recommended to split the administration (e.g., one dose in the morning and one in the early afternoon) to maintain steady blood levels of the active compounds throughout the day