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In contrast, the amino acid positions where substitutions have been tolerated by natural selection indicates that these positions are not critical for protein function

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One approach involves antioxidant therapies aimed at neutralizing the ROS generated by pyocyanin or boosting endogenous antioxidant defenses such as glutathione (206)

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The response rate was equally impressive: 91.7% of participants on the 12 mg dose achieved at least 10% total body weight reduction

This might possibly be due to the engineered control circuits responding to the target product intermediate, limiting any improvement in production beyond initial control levels