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*Correspondence: Liang Hu, [email protected] Wu, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

It has been observed that such mitochondrial impairments facilitate the opening of the mitochondrial permeability transition pore (mPTP), causing the release of cytochrome C (Cyt C) from the intermembrane space (52)

Furthermore, the results presented herein neither endorse the prophylactic use of B12 to prevent SARS-CoV-2 infection, nor its therapeutic use in mild COVID-19

It can lead to isolation, strained relationships, and, in severe cases, suicidal thoughts

Neuropeptide Y induced modulation of dopamine synthesis in the striatum

Although it is not known if prophylactic vitamin B 12 supplementation prevents deficiency, it seems prudent to monitor vitamin B 12 levels periodically in patients taking metformin