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While the IOM had based B12 needs on the amount required to correct hematological parameters for people with pernicious anemia, the EFSA had almost 20 more years of research to draw on, and concluded that the most suitable approach was basing needs on biomarkers (serum B12, holotranscobalamin, MMA, and homocysteine)

These deficiencies can lead to a variety of health issues, including a weakened immune system, digestive problems, skin conditions, heart complications, eye ailments, and impaired bone growth

Though the recommended doses are not expected to cause adverse effects for the infant, there are no human studies available to assess the risks

Tastet, et al

However, the effects can be accelerated and improved by combining AOD with a nutritious diet and consistent exercise