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With the discovery of cuproptosis (205-207), the interactions between copper ionophores (208,209), copper and mitochondria, and drugs that had previously been considered as potential anti-tumor therapies (71), have become increasingly clear

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Even more recently completed trials have struggled with diverse enrollmenta Phase 2 trial of crenezumab in Alzheimers disease with 360 participants across 83 sites in 6 countries reported 97.5 percent of participants being white, and only 2.8 percent of all participants being Hispanic, for example (however, women consisted of 55.3 percent of all participants)

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