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27 Penile Prostheses: Penile prostheses are considered third-line treatment options due to the need for surgical implantation of the devices

doi:10.1002/cmdc.v19.10

Standard injection protocol: Dose: 1 to 2 mg daily Duration: 10 to 20 day cycles Frequency: 1 to 3 cycles per year, spaced 4 to 6 months apart Timing: Evening administration to align with natural melatonin production timing Administration: Subcutaneous or intramuscular Maintenance protocol (sublingual): Daily sublingual sprays between injection cycles Lower bioavailability than injection but convenient for ongoing support The cyclic nature of Epitalon protocols reflects how the peptide works

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doi: 10.1038/s41598-021-93420-4 19 KopfMABonnetDArtaudIPtrDMansuyD