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Beyond lipid metabolism, transcriptomic analysis also revealed that SR4 induces a broader metabolic reprogramming in the liver of db/db mice

320,324 Circulation High circulating tumor cell (CTC) counts are positively correlated with poor survival rates in patients with cancer

Preclinical studies in in vitro models have shown that simvastatin exerted its anti-tubercular activity through cholesterol-driven autophagy, which is mediated by the adenosine monophosphate-activated protein kinase (AMPK)mammalian target of the rapamycin complex 1 (mTORC1)TFEB axis [58] (Fig

2021), binds to milk fat globule-EGF factor 8 (MFG-E8), which is essential for phagocytosis of apoptotic cells by inflammatory monocytes (Uderhardt 2012)