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"Glutathione production requires methylation." From this perspective, increasing glutathione from external sources (food and supplements) can take the pressure off the methylation cycle and glutathione production

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Clinical studies provide indirect evidence of this process through fluid biomarkers: elevated serum and CSF levels of S100, an astrocytic protein that can leak into the bloodstream following BBB disruption and CSF during disease, have been reported in PD cohorts and correlate with disease severity, suggesting both astrocytic reactivity and vascular compromise (Sathe et al., 2012)

1a, left panel) or mRNA expression (Fig

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doi: 10.1038/nm1611 90 PandolfiJFerraroALernerMSerranoJRDueckAFainboimLet al