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doi:10.1016/j.amjmed.2004.03.032

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It is not a single synthetic peptide but rather a complex mixture of low molecular weight neuropeptides and free amino acids derived from porcine brain tissue

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this occurs because there is not enough vitamin B12 in the diet or poor absorption Pernicious anemiaa type of megaloblastic anemia caused by a lack of intrinsic factor so that vitamin B12 is not absorbed Fatigue, weakness Nerve damage with numbness, tingling in the hands and legs Memory loss, confusion Dementia Depression Seizures Toxicity Toxicity Vitamin B12 is a water-soluble vitamin, so any unused amount will exit the body through the urine

Results of the Phase 1 study demonstrated that, as expected, renal impairment markedly affects pudexacianinium PK, with apparent increases in plasma exposure and slower excretion into urine in participants with renal impairment compared with in healthy participants with normal renal function