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The Johns Hopkins University

When a cell over-expresses NNMT, it does two costly things at once: it burns through methyl-donor capacity, and it diverts nicotinamide away from NAD+ regeneration into an inert metabolite (1-methylnicotinamide) that gets excreted

This medication is commonly used as an ovulation trigger shot during assisted reproductive protocols and as a therapeutic agent in male infertility and hypogonadism