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Studies using patient derived fibroblasts showed loss of FDXR function led to decreased enzyme activity, reduced functions of Complexes I-III, significant increase in reactive oxygen species production, and mitochondrial iron overload [84,85]

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[DOI] [PubMed] [Google Scholar] 80.Connelly-Smith L., Dunbar N.M

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Ngf overexpression led to prominent PNI and enlarged intratumoral nerves [21]

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