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This activation of TRIB1 led to the blockade of TLR2/NF-B signalling, a reduction in p-p65 and p-IB levels, and a subsequent reduction in the expression of the inflammatory factors IL-1, IL-6 and IL-8

Therefore, corticosteroid therapy for SLE requires tailored strategies and close monitoring to balance benefits and manage potential adverse effects

Purine and pyrimidine metabolism: convergent evidence on chronic antidepressant treatment response in mice and humans

Even though their advantages, several important restrictions exist