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Second, the number of M1like macrophages was not altered by eosinophil depletion, but decreased in mice receiving IL4c (Fig 6E)

Additionally, in vitro studies have demonstrated that zinc chelation inhibits AID activity, suggesting that age-associated changes in zinc homeostasis might further exacerbate the reduction in AID functionality [368]

10.1016/S0891-5849(02)01009-2

TLR4 can activate the NLRP3 inflammasome and cause microglial pyroptosis in SCI mouse models via the Janus kinase 2/signal transducer and activator of transcription 1/dead-box helicase 3 X-linked/NLRP3 signaling pathway (Wang et al., 2022b)

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Absence of COA documentation or reluctance to provide testing results raises immediate concerns