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Since nucleotide supply plays a critical role in DNA replication, we further performed DNA fiber assay by measuring the lengths of chase IdU-labeled DNA replication tracks that link to pulse CldU-labeling, which is a gold standard for assessing replication stress 32

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The system Xc- transporter is a target upstream of the ferroptosis pathway [10, 46, 65,66,67]

The reason for this decrease is unclear since PSC activation (as assessed by -SMA staining) in this group was unchanged compared to other groups

doi: 10.1210/me.2010-0051 33 SinclairDWebsterMJWongJWeickertCS