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Este equilibrio redox regula diversos procesos metablicos intracelulares que incluyen la actividad enzimtica, el transporte celular, transduccin de seales y la expresin gnica mediada por la transcripcin de factores entre los que se destacan el activador de protena (AP-1), el factor nuclear kappa-p ( NF k-B) y el p53 (4)(26)(33)

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While the exact sequence of events and identity of all the mediators involved in the process are still being investigated, hepatocytes after an APAP overdose die by regulated necrosis

However, it fluctuates between 5.5 and 7.0 (Mazinani et al., 2020)